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Human p53 circRNA refers to circular RNA molecules that interact with or are regulated by the p53 protein, a critical tumor suppressor involved in maintaining genomic stability and preventing cancer. These circRNAs can modulate p53 activity through various mechanisms, such as stabilizing p53 by disrupting its interaction with MDM2 or acting as miRNA sponges to influence downstream gene expression. They play diverse roles in cancer, with some promoting tumor suppression by enhancing p53 function, while others may contribute to cancer progression. Understanding these complex interactions provides valuable insights into cancer biology and opens new avenues for developing therapeutic strategies targeting p53-related circRNAs.
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