Name: DMTr-2'-O-Et-rA(Bz)-3'-CE-Phosphoramidite
Brand: BOC Sciences
Rating: 5 (1 reviews)

DMTr-2'-O-Et-rA(Bz)-3'-CE-Phosphoramidite

DMTr-2'-O-Et-rA(Bz)-3'-CE-Phosphoramidite, utilized in oligonucleotide synthesis, contains an ethyl (Et) group at the 2'-O position, and a benzoyl (Bz) protecting group on the adenine amino group. The 3'-end is functionalized with a cyanoethyl (CE) group, facilitating efficient coupling reactions during solid-phase synthesis. It is employed to introduce modified adenine residues into nucleic acid sequences, enhancing stability and target specificity for various molecular biology applications, including RNA labeling, gene synthesis, and RNA interference studies.

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Catalog

BRP-00625

Synonyms

(2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-ethoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

IUPAC Name

N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-ethoxyoxolan-2-yl]purin-6-yl]benzamide

Molecular Weight

902.00

Molecular Formula

C49H56N7O8P

SMILES

CCOC1C(C(OC1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)OP(N(C(C)C)C(C)C)OCCC#N

InChI

InChI=1S/C49H56N7O8P/c1-8-60-44-43(64-65(62-29-15-28-50)56(33(2)3)34(4)5)41(63-48(44)55-32-53-42-45(51-31-52-46(42)55)54-47(57)35-16-11-9-12-17-35)30-61-49(36-18-13-10-14-19-36,37-20-24-39(58-6)25-21-37)38-22-26-40(59-7)27-23-38/h9-14,16-27,31-34,41,43-44,48H,8,15,29-30H2,1-7H3,(H,51,52,54,57)/t41-,43-,44-,48-,65?/m1/s1

InChIKey

BWEYMSXPRQAMFY-FVPMUMJWSA-N

Purity

≥95%

Storage

Store at -20 °C

Chemical Structure:

Chemical structure of BRP-00625