Name: DMTr-2'-O-EOE-rA(Bz)-3'-CE-Phosphoramidite
Brand: BOC Sciences
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DMTr-2'-O-EOE-rA(Bz)-3'-CE-Phosphoramidite

DMTr-2'-O-EOE-rA(Bz)-3'-CE-Phosphoramidite is used in oligonucleotide synthesis and contains a 2'-O-ethoxyethyl (EOE) group at the 2'-position of adenosine (rA), along with benzoyl (Bz) protection on the adenine amino group. Additionally, it features a cyanoethyl (CE) group at the 3'-end to facilitate efficient coupling reactions during solid-phase synthesis. It is employed to introduce modified adenosine residues into RNA sequences, enhancing stability and target specificity.

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Catalog

BRP-00615

Synonyms

(2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-ethoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

IUPAC Name

N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-(2-ethoxyethoxy)oxolan-2-yl]purin-6-yl]benzamide

Molecular Weight

946.05

Molecular Formula

C51H60N7O9P

SMILES

CCOCCOC1C(C(OC1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)OP(N(C(C)C)C(C)C)OCCC#N

InChI

InChI=1S/C51H60N7O9P/c1-8-62-30-31-63-46-45(67-68(65-29-15-28-52)58(35(2)3)36(4)5)43(66-50(46)57-34-55-44-47(53-33-54-48(44)57)56-49(59)37-16-11-9-12-17-37)32-64-51(38-18-13-10-14-19-38,39-20-24-41(60-6)25-21-39)40-22-26-42(61-7)27-23-40/h9-14,16-27,33-36,43,45-46,50H,8,15,29-32H2,1-7H3,(H,53,54,56,59)/t43-,45-,46-,50-,68?/m1/s1

InChIKey

FXYAXMLJVORSBX-SXQANJJUSA-N

Purity

≥95%

Storage

Store at -20 °C

Chemical Structure:

Chemical structure of BRP-00615