CTP-αS

CTP-αS is a modified form of cytidine triphosphate (CTP). In CTP-αS, the oxygen atom in the α-phosphate group of CTP is replaced by a sulfur atom, resulting in a non-hydrolyzable analog of CTP. This modification allows CTP-αS to mimic the structure of CTP while preventing its hydrolysis. CTP-αS is commonly used in biochemical and molecular biology research to study CTP-dependent processes, such as RNA synthesis, RNA splicing, and other nucleic acid-related processes.

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Catalog

BRP-00448

Synonyms

Cytidine, 5'→P''-ester with thiotriphosphoric acid; Cytidine-5'-O-(1-thiotriphosphate); CTPαS; Alpha Thiol CTP (1-Thio-CTP)

CAS

110972-40-2

IUPAC Name

[[(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl] phosphono hydrogen phosphate

Molecular Weight

499.22

Molecular Formula

C9H16N3O13P3S

SMILES

C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=S)(O)OP(=O)(O)OP(=O)(O)O)O)O

InChI

InChI=1S/C9H16N3O13P3S/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(23-8)3-22-28(21,29)25-27(19,20)24-26(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,29)(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-,28?/m1/s1

InChIKey

MBIHBEVUNFGMSS-NOUWQNLYSA-N

Boiling Point

805.3±75.0 °C at 760 mmHg

Purity

≥95% by HPLC

Density

2.44±0.1 g/cm3

Storage

Store at -20 °C

Related CAS

118353-34-7 (S-isomer) 118374-59-7 (R-isomer)