BiotinTEG Phosphoramidite - CAS 198080-44-3

Catalog number: BRI-005

5'-Biotin Phosphoramidite for direct labeling of synthetic oligonucleotides has the following characteristics:

Soluble in acetonitrile at concentrations useful for DNA synthesis.
Include the DMT group used for cassette purification, which is essential for the preparation of biotinylated PCR primers because cross-contamination may occur during HPLC purification.
To develop diagnostic probes, biotin phosphoramidite can be branched to allow the introduction of multiple biotins at the 3'or 5'end.
Contains a 15 atom mixed polar spacer based on triethylene glycol.

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Synonyms

1-Dimethoxytrityloxy-3-O-(N-biotinyl-3-aminopropyl)-triethyleneglycolyl-glyceryl-2-O-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite

CAS

198080-44-3

IUPAC Name

N-[3-[2-[2-[2-[3-[bis(4-methoxyphenyl)-phenylmethoxy]-2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropoxy]ethoxy]ethoxy]ethoxy]propyl]-5-(2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl)pentanamide

Molecular Weight

1010.24

Molecular Formula

C52H76N5O11PS

Canonical SMILES

CC(C)N(C(C)C)P(OCCC#N)OC(COCCOCCOCCOCCCNC(=O)CCCCC1C2C(CS1)NC(=O)N2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

InChI

InChI=1S/C52H76N5O11PS/c1-39(2)57(40(3)4)69(67-29-12-26-53)68-46(37-66-52(41-14-8-7-9-15-41,42-18-22-44(60-5)23-19-42)43-20-24-45(61-6)25-21-43)36-65-35-34-64-33-32-63-31-30-62-28-13-27-54-49(58)17-11-10-16-48-50-47(38-70-48)55-51(59)56-50/h7-9,14-15,18-25,39-40,46-48,50H,10-13,16-17,27-38H2,1-6H3,(H,54,58)(H2,55,56,59)

InChIKey

JHOFQGWLXUQCDS-UHFFFAOYSA-N

Purity

≥95% (NMR)

Appearance

Off-white Solid

Storage

store at -20 °C

Symbol

BIOTIN-TEG CEP

Formulation

Dilute with anhydrous acetonitrile

Chemical Structure: