5'-DMT-A(PAC)-Suc-CPG; 1000 Å (RNA)

Catalog number: BRP-02252

5'-DMT-A(PAC)-Suc-CPG; 1000 Å (RNA)

5'-DMT-A(PAC)-Suc-CPG is used to incorporate unmodified ribonucleic acid at the 3 end of the oligonucleotide.

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.
Catalog
BRP-02252
Synonyms
5'-O-DMT-2'-OAc-A(Pac)-3'-0-Suc-CPG
Appearance
White powder
Storage
Store at 2-8 °C
Shipping
Room temperature.
Synthesis Conditions
If you use PAC-protected supports or reagents, we recommend using phenoxyacetic anhydride or tert-butylbenzene acetal anhydride (FAST deprotection cap) as the CAPA reagent. Standard acetic anhydride (CAP A) can cause the acetylation of PAC-protected primary amines during the synthesis process.
Cleavage Conditions
Use concentrated ammonia for 90 min at 25°C or 30 min at 60°C, or 1:1 ammonia:methylamine (AMA) for 25 min at 25°C when using fast deprotecting amidites.
Deprotection Conditions
When using fast deprotection amidites (such as C-Ac; G-DMF), use concentrated ammonia at 60°C for 1h or AMA for 30 min. When using standard amidites (such as C-Bz; G-iBu), please use concentrated ammonia at 60°C for 5h.

Chemical Structure:

Reference Reading

1. The pulmonary artery catheter: is it still alive?
Daniel De Backer, Jean-Louis Vincent. Curr Opin Crit Care. 2018 Jun;24(3):204-208. doi: 10.1097/MCC.0000000000000502.
The present review discusses the current role of the pulmonary artery catheter (PAC) in the hemodynamic monitoring of critically ill patients. The PAC has an important role in the characterization and management of hemodynamic alterations in critically ill patients. Use of the PAC has decreased in the last 30 years because of recent advances in less invasive hemodynamic monitoring techniques, in particular transpulmonary thermodilution and echocardiography, combined with the publication of the results of several randomized trials that failed to show improvements in outcome with the use of the PAC in various settings. Although it is obvious that the PAC should not be used in most critically ill patients, the PAC is still indicated in some patients with circulatory and/or respiratory failure, especially when associated with pulmonary hypertension or left heart dysfunction. As for any technique, optimal PAC use requires expertise in insertion, acquisition, and interpretation of measurements. The decrease in use of the PAC may unfortunately limit exposure of junior doctors and nurses to this device, so that they become less familiar with using the PAC, making it more complicated and less optimal. The PAC still has an important role in the cardiopulmonary monitoring of critically ill patients.
2. Invasive hemodynamic monitoring
Sheldon Magder. Crit Care Clin. 2015 Jan;31(1):67-87. doi: 10.1016/j.ccc.2014.08.004.
Although invasive hemodynamic monitoring requires considerable skill, studies have shown a striking lack of knowledge of the measurements obtained with the pulmonary artery catheter (PAC). This article reviews monitoring using a PAC. Issues addressed include basic physiology that determines cardiac output and blood pressure; methodology in the measurement of data obtained from a PAC; use of the PAC in making a diagnosis and for patient management, with emphasis on a responsive approach to management; and uses of the PAC that are not indications by themselves for placing the catheter, but can provide useful information when a PAC is in place.
3. Non-pharmacological remedies for post-viral acute cough
Giorgio Ciprandi, Maria Angela Tosca. Monaldi Arch Chest Dis. 2021 Aug 10;92(1). doi: 10.4081/monaldi.2021.1821.
The post-viral acute cough (PAC) is a widespread symptom, mainly in childhood and adolescence, and is usually associated with an acute upper respiratory infection, namely the common cold. The use of cough relievers is, therefore, impressive, as documented by the market data. There are many medical devices and dietary supplements for treating PAC, which contain non-pharmacological components. Ancient people used traditional herbs to treat PAC. Thus, a well-established tradition considers natural remedies as an effective and safe way to relieve PAC. The herbal agents include polyphenols, flavonoids, saponins, glucosides, and alkaloids. Also, the European Medicine Agency has recognized the value of plant extracts and other natural substances to treat PAC. Nevertheless, a few studies investigated the role of non-pharmacologic remedies for PAC. There is some evidence for honey, glycerol, Althea officinalis, Drosera rotundifolia, Grindelia, Hedera helix, Pelargonium sidoides, Sambucus nigra, Thymus vulgaris, hyaluronic acid, and saline solutions. However, further rigorous studies should confirm natural products' efficacy and safety to relieve PAC.
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