Name: 10-O-[1-Propyl-3-N-carbamoylcholesteryl]-TEG-CE phosphoramidite
Brand: BOC Sciences
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10-O-[1-Propyl-3-N-carbamoylcholesteryl]-TEG-CE phosphoramidite

10-O-[1-Propyl-3-N-carbamoylcholesteryl]-TEG-CE phosphoramidite, an activator for viral RNA replication, is a specialized reagent used in the synthesis of modified oligonucleotides, particularly in the context of creating conjugated or functionalized nucleic acids. This reagent is particularly useful in the development of oligonucleotide-based drugs, where conjugation with lipophilic molecules like cholesterol can significantly improve the drug's performance.

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Catalog

BRP-02215

Synonyms

5'-Cholesterol-TEG-CE Phosphoramidite; 10-O-[1-Propyl-3-N-carbamoylcholesteryl]-triethyleneglycol-1-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Cholest-5-en-3-ol (3β)-, 3-[16-[bis(1-methylethyl)amino]-19-cyano-6,9,12,15,17-pentaoxa-2-aza-16-phosphanonadecanoate]; 5'-Cholesteryl TEG phosphoramidite

CAS

1325147-19-0

IUPAC Name

[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] N-[3-[2-[2-[2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyethoxy]ethoxy]ethoxy]propyl]carbamate

Molecular Weight

820.13

Molecular Formula

C46H82N3O7P

Canonical SMILES

CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC(=O)NCCCOCCOCCOCCOP(N(C(C)C)C(C)C)OCCC#N)C)C

InChI

InChI=1S/C46H82N3O7P/c1-34(2)13-10-14-37(7)41-17-18-42-40-16-15-38-33-39(19-21-45(38,8)43(40)20-22-46(41,42)9)56-44(50)48-24-12-25-51-27-28-52-29-30-53-31-32-55-57(54-26-11-23-47)49(35(3)4)36(5)6/h15,34-37,39-43H,10-14,16-22,24-33H2,1-9H3,(H,48,50)/t37-,39+,40+,41-,42+,43+,45+,46-,57?/m1/s1

InChIKey

XIXYNNLTICMGJD-CYNTUAGHSA-N

Boiling Point

777.0±60.0 °C at 760 mmHg

Purity

≥95%

Solubility

Soluble in Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Appearance

Colorless oil to heavy oily matter

Storage

Store at -20 °C

Chemical Structure:

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10-O-[1-Propyl-3-N-carbamoylcholesteryl]-TEG-CE phosphoramidite - CAS 1325147-19-0

10-O-[1-Propyl-3-N-carbamoylcholesteryl]-TEG-CE phosphoramidite