2'-O-Methyl-U-Suc-CPG; 500 Å (RNA)

2'-O-Methyl-U-Suc-CPG; 500 Å is a reagent used in the solid-phase synthesis of RNA oligonucleotides, specifically for incorporating 2'-O-methyluridine residues. It features a succinyl linker that attaches the 2'-O-methyluridine to controlled pore glass (CPG) with a 500 Å pore size. The 2'-O-methyl modification enhances the stability and resistance of the RNA to enzymatic degradation, making this reagent ideal for creating more stable and durable RNA sequences with precise uridine incorporation.

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Catalog

BRP-02245

Synonyms

5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyluridine-3'-Suc-CPG 500 Å; 2'-O-methyl-5'-O-DMT-uridine-3'-Suc-CPG 500 Å; 2'-O-methyl-5'-O-dimethoxytrityluridine-3'-Suc-CPG 500 Å

Appearance

White to off-white powder

Storage

Store at -20 °C

Symbol

2'-OMe-U-RNA-CPG

Shipping

Room temperature.

Cleavage Conditions

Use concentrated ammonia for 90 minutes at 25°C or for 30 minutes at 60°C.

Deprotection Conditions

When using fast deprotection amidites (such as C-Ac; G-DMF), use concentrated ammonia at 60°C for 1 hour or AMA for 30 minutes. When using standard amidites (such as C-Bz; G-iBu), please use concentrated ammonia at 60°C for 5 hours. Compatible with the deprotection chemicals used by 2' Fluoro; 2' modified phosphoramidite and TBDMS protected reagents.

Chemical Structure: