Name: LNA-5-Me-C(Bz)-CE Phosphoramidite
Brand: BOC Sciences
Rating: 5 (1 reviews)

LNA-5-Me-C(Bz)-CE Phosphoramidite

LNA-5-Me-C(Bz)-CE Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It features a locked nucleic acid (LNA) backbone with a 5-methylcytosine base modified with a benzoyl (Bz) group. Additionally, it includes a 5'-cyanoethyl (CE) phosphoramidite functionality, allowing for controlled addition during synthesis. LNAs are known for their enhanced hybridization properties and stability, making this phosphoramidite useful for applications requiring high-affinity binding and specificity, such as antisense oligonucleotide therapy, SNP detection, and diagnostic assays in molecular biology research.

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Catalog

BRP-00387

Synonyms

5'-O-DMTr-2'-O-4'-C-Locked-5-Me-C(Bz) Phosphoramidite; DMT-locMeC(bz)Amidite; DMT-locMeC(bz) phosphoramidite; N-[1-[2,5-Anhydro-5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-α-L-lyxofuranosyl]-1,2-dihydro-5-methyl-2-oxo-4-pyrimidinyl]benzamide; DMTr-LNA-5MeC(Bz)-3-CED-phosphoramidite; N4-benzoyl-5-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-4'-C-Locked-cytidine-3'-cyanoethyl Phosphoramidite; LNA-5MeC(Bz)-3-CED-phosphoramidite; Bz-5-Me-C-LA-CE Phosphoramidite; DMT-2'-O-4'-C-Locked-5-Me-C(Bz)-CE; LNA-5mC(Bz) phosphoramidite; N4-Bz-2'-O-4'-C-Locked-5-Me-Cr-CE-Phosphoramidite

CAS

206055-82-5

IUPAC Name

N-[1-[(1R,3R,4R,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-5-methyl-2-oxopyrimidin-4-yl]benzamide

Molecular Weight

875.96

Molecular Formula

C48H54N5O9P

Canonical SMILES

CC1=CN(C(=O)N=C1NC(=O)C2=CC=CC=C2)C3C4C(C(O3)(CO4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)OP(N(C(C)C)C(C)C)OCCC#N

InChI

InChI=1S/C48H54N5O9P/c1-32(2)53(33(3)4)63(60-28-14-27-49)62-42-41-45(52-29-34(5)43(51-46(52)55)50-44(54)35-15-10-8-11-16-35)61-47(42,30-58-41)31-59-48(36-17-12-9-13-18-36,37-19-23-39(56-6)24-20-37)38-21-25-40(57-7)26-22-38/h8-13,15-26,29,32-33,41-42,45H,14,28,30-31H2,1-7H3,(H,50,51,54,55)/t41-,42+,45-,47-,63?/m1/s1

InChIKey

XHILZPWJJJDDDY-HXAWEXODSA-N

Purity

≥95%

Appearance

Off-white to yellow powder

Storage

Store at -20 °C

Chemical Structure: